Factor V Leiden Mutation
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Risk Factors for Factor V Leiden Mutation

What are the risks to the person with factor V Leiden mutation?

If you are factor V Leiden mutation heterozygous you may be at a higher risk for a blood clot or a thrombosis. Statistics in the research state that a heterozygous person can go their whole life and never experience any effects of having factor V Leiden mutation. Homozygous persons have an even higher risk of getting a blood clot or a thrombosis because both of their factor V Leiden genes are mutated. This means that they have a higher risk of having a blood clot or thrombosis.

What are risks to family members of a person with factor V Leiden mutation?

The risks to family members depends on whether they have the factor V Leiden mutation. Whether or not siblings of the person with factor V Leiden mutation have factor V Leiden depends on the parents. It is genetically proven that if one parent is heterozygous the children have a 50% chance of being heterozygous for factor V Leiden. If one parent is homozygous the children have a 100% chance for being heterozygous for factor V Leiden mutation. If both parents are heterozygous the children have a 50% chance of being heterozygous, a 25% chance of being homozygous and a 25% of having both normal factor V Leiden genes. One parent of a heterozygous child for the factor V Leiden mutation is also heterozygous for the factor V Leiden mutation. If the child is homozygous one parent has to be homozygous or both parents have to be heterozygous.